Recent developments in biased agonism
نویسندگان
چکیده
منابع مشابه
Biased agonism
Seven-transmembrane receptors are commonly coupled to multiple signaling pathways in cells. The simple model describing agonists for these receptors as producing a common active state to induce uniform activation of the pathways linked to the receptor has been shown to be untenable in light of a large body of data that suggest that some agonists produce activation of some but not all available ...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2014
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2013.10.008